GENERAL CATALOGUE
SKLB-11A
HY-173572 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-173572
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Catalog No: HY-173572
CAS No: 433953-86-7
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SKLB-11A is a selective, orally active and allosteric SIRT3 sirtuin 3 agonist with a Kd value of 4.7 ?M. SKLB-11A is highly selective for other members of the SIRT family. SKLB-11A activates autophagy-related signaling pathways, prevents mitochondrial dysfunction, improves cardiac function in Doxorubicin HY-15142A -induced cardiotoxicity and myocardial ischemia/reperfusion models.
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