GENERAL CATALOGUE
SKLB-D18
HY-173119 · 5 mg
MedChemExpress · Cat: HY-173119
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medchemexpress.com/sklb-d18.htmlCatalog No: HY-173119
Category: Autophagy
Pack Size: 5 mg
Brand: MedChemExpress
Description
SKLB-D18 is a potent and selective inhibitor of ERK1/2 and ERK5, with IC50s of 38.69, 40.12?and 59.72 nM, respectively. SKLB-D18 is also an autophagy agonist, plays a role in mTOR/p70S6K and NCOA4-mediated ferroptosis, which may mitigate multidrug resistance. SKLB-D18 exhibits significantly superior efficacy in vitro and in vivo against triple-negative breast cancer TNBC .
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