GENERAL CATALOGUE
SL44
HY-162650 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-162650
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Catalog No: HY-162650
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SL44 is an agonist for human caseinolytic protease P HsClpP , with an EC50 of 1.30 ?M. SL44 inhibits the proliferation of LM3 with an IC50 of 3.1 ?M. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity LD50=400 mg/kg . SL44 exhibits good pharmacokinetic characters in rat models.
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