GENERAL CATALOGUE
SMTIN-T140
HY-147696 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-147696
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Manufacturer product page
medchemexpress.com/smtin-t140.htmlCatalog No: HY-147696
CAS No: 2851532-40-4
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SMTIN-T140 compound 6a is a potent TRAP1 tumor-necrosis-factor-receptor associated protein 1 inhibitor, with an IC50 of 1.646 ?M. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells.
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