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SMU-14a
GENERAL CATALOGUE

SMU-14a

HY-176192 · 50 mg

MedChemExpress · Cat: HY-176192

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medchemexpress.com/smu-14a.html
Catalog No: HY-176192
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

SMU-14a is a TLR3 inhibitor IC50: 0.18 AAasAasAAmuM . SMU-14a inhibits IL-6 secretion in mouse peritoneal macrophages and downregulates TNF-? in human peripheral blood monocytes. SMU-14a exerts anti-inflammatory effects by reducing the phosphorylation of p65, ERK, and TBK1 through NF-?B, MAPK, and IRF3 signaling pathways, and decreasing serum alanine aminotransferase ALT and aspartate aminotransferase AST levels. SMU-14a can be used in the study of acute hepatitis.

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