GENERAL CATALOGUE
SMU127
HY-122566 · 500 g
MedChemExpress · Cat: HY-122566
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medchemexpress.com/smu127.htmlCatalog No: HY-122566
CAS No: 903864-87-9
Category: Apoptosis
Pack Size: 500 g
Brand: MedChemExpress
Description
SMU127 is an agonist of the toll-like receptor 1/2 TLR1/2 heterodimer. It induces NF-?B signaling in cells expressing human TLR2 EC50=0.55 ?M but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 ?M. SMU127 induces the production of TNF-? in isolated human peripheral blood mononuclear cells PBMCs when used at concentrations ranging from 0.01 to 1 ?M. In vivo, SMU127 0.1 mg/animal reduces tumor volume in a 4T1 murine mammary carcinoma model.
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