GENERAL CATALOGUE
SNX-2112
HY-10214 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-10214
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Catalog No: HY-10214
CAS No: 908112-43-6
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SNX-2112 PF 04928473 is an orally active Hsp90 inhibitor, with a Kd of 16 nM for Hsp90 and IC50s of 30 nM, 30 nM for Hsp90 ? and Hsp90 ?, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50s of 10 nM, 4.275 ?M and 0.862 ?M, respectively. SNX-2112 PF 04928473 binds Hsp90 isoforms Hsp90?, Hsp90? and Hsp90b1/Grp94 with Kds of 4 nM, 6 nM and 484 nM, respectively.
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