Sodium dichloroacetate

Description

Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase PDK inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase PDH activity and works as a Na+-K+-2Cl? cotransporter NKCC inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1? subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species ROS . Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers.