SOS1/EGFR-IN-1

Description

SOS1/EGFR-IN-1 compound SE-9 is a dual-target inhibitor for the prostate cancer. SOS1/EGFR-IN-1 inhibits effectively SOS1 IC50=42.13AAasAasAA+/-1.55 nM and EGFR IC50=1.01AAasAasAA+/-0.04 nM by inhibiting their downstream effector molecules. SOS1/EGFR-IN-1 induces apoptosis and G1 phase cell cycle arrest, reducing angiogenesis and migration. SOS1/EGFR-IN-1 shows significant antitumor effects in prostate cancer cells PC-3 IC50=0.45AAasAasAA+/-0.03 ?M .