GENERAL CATALOGUE
SOS1-IN-17
HY-168716 · 50 mg
MedChemExpress · Cat: HY-168716
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medchemexpress.com/sos1-in-17.html
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Catalog No: HY-168716
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
SOS1-IN-17 Compound 8d is an orally active inhibitor for SOS1-KRASG12C interaction with an IC50 of 5.1 nM. SOS1-IN-17 inhibits ERK phosphorylation in DLD-1 cell with an IC50 of 18 nM. SOS1-IN-17 exhibits anti-proliferative activity in KRASG12C mutated Mia-Paca-2 cell with an IC50 of 0.11 ?M. SOS1-IN-17 exhibits antitumor efficacy against pancreatic cancer in mouse model.
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