SOS1-IN-20

Description

SOS1-IN-20 Compound 12f is an orally active SOS1 inhibitor with an IC50 of 5.11 nM against KRASG12C::SOS1. By disrupting the interaction between KRAS and SOS1, SOS1-IN-20 inhibits KRAS activation and downstream signal transduction. SOS1-IN-20 has an IC50 of 253 nM for p-ERK in PC-9 cells and 16.71 ?M for hERG channel . SOS1-IN-20 can inhibit the proliferation of tumor cells and has antitumor activity.