GENERAL CATALOGUE
Sotorasib
HY-114277 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-114277
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Manufacturer product page
medchemexpress.com/AMG-510.htmlCatalog No: HY-114277
CAS No: 2296729-00-3
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Sotorasib AMG-510 is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C?mutated locally advanced or metastatic non?small cell lung cancer NSCLC .
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