SP100 Stable Knockout HEp-2 Cell Line

Description

Nuclear domain 10 ND10 bodies are membrane-less cellular components found in the nucleus that affect transcription and are implicated in some immune functions. ND10 bodies are able to detect and respond to viruses that infect cells although many viruses have evolved to degrade or evade these ND 10 bodies. HSV-1 virus has the ability to degrade both the SP100 and PML ND10 bodies. Other viruses even have the ability to repurpose ND10 bodies to use in their replication. The SP100 Stable Knockout HEp-2 Cell Line has been previously used in research to better understand the role of ND10 bodies SP100 host defences against viral infection. The cell line is ideal for virology research and studies pertaining to innate immune defences at the cellular level.