GENERAL CATALOGUE
SPC-180002
HY-155784 · 50 mg
MedChemExpress · Cat: HY-155784
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Catalog No: HY-155784
CAS No: 2170274-53-8
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 ?M, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway.
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