Spexin

Description

Spexin Neuropeptide Q is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation e.g., reducing the respiratory exchange ratio in rodents . Spexin improves cardiac function in the Doxorubicin hydrochloride HY-15142 -induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases e.g., cardioprotection , and side effects of tumor chemotherapy.