GENERAL CATALOGUE
SR-0813
HY-145409 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-145409
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Catalog No: HY-145409
CAS No: 2597186-19-9
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM CETSA for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity Kd=3.5 ?M than ENL YEATS Kd=30 nM . SR-0813 can be used for the research of acute leukemia.
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