ST-899

Description

ST-899 is a novel platelet-activating factor PAF receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin LPS -induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor TNF levels induced by LPS, but has no effect on interleukin-6 IL-6 . The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock.