Stable GS-3A4-HepG2 Cell Line

Description

The parental cell line of GS-3A4-HepG2 HepG2 was derived from a human hepatoma and was transformed with a vector containing the Glutamine Synthetase gene allowing for ammonia metabolism and the 3A4 gene for drug metabolism. This transformation allows for activity in the immortalized cell line that is similar to primary hepatocytes but with a greater ability to metabolise drugs 3A4 activity . This cell line is highly functional in long term culture and therefore ideal for continuous research into liver function and metabolism. Previous studies have explored the cell lines use into bioartificial liver support systems. These systems are new technologies being developed to treat cases of liver damage where function needs to be supported during liver regeneration. The GS-3A4-HepG2 cell line may be particularly useful to metabolism drugs during long term experiments.