STAT3-IN-27

Description

STAT3-IN-27 Compound 41 is an orally active inhibitor for phosphorylation of STAT3 KD is 4.4 ?M and STAT3 transcription IC50 is 22.57 nM . STAT3-IN-27 inhibits proliferation of various cancer cells with IC50 of 10-500 nM. STAT3-IN-27 arrests the cell cycle at G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116, inhibits cell migration of HCT116. STAT3-IN-27 exhibits antitumor efficacy in mouse model.