STAT3-IN-31

Description

STAT3-IN-31 compound K2071 is a STATtic-derived STAT3 and mitotic inhibitor. STAT3-IN-31 blocks mitotic progression and affects the formation of mitotic spindles. STAT3-IN-31 also affects glioblastoma cell migration and inhibits cell proliferation in tumor spheroids. STAT3-IN-31 is also able to induce glioblastoma senescence, inhibit the growth of Temozolomide HY-17364 -resistant cells and the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein MCP-1.