STAT3 Mouse Monoclonal Antibody

Description

EnkiLife offers the STAT3 Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Monkey species and is suitable for WB,IHC,ICC,ELISA application. Alternative Names of Immunogen: APRF; HIES; FLJ20882; MGC16063; STAT3. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:200-1:1000,ICC 1:200-1:1000,ELISA 1:5000-1:20000 Background: The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3a (86 kDa) and Stat3 Research Area: Jak-STAT signaling pathway