STAT3/NF-?B-IN-1

Description

STAT3/NF-?B-IN-1 is a potentSTAT3 and NF-?B inhibitor with IC50s of 5.86 STAT3 and 4.22 ?M NF-?B in 4T1 cells. STAT3/NF-?B-IN-1 is able to induce apoptosis via its upregulation on key apoptotic regulators; caspases-3/9, Bax and downregulation of Bcl-2. STAT3/NF-?B-IN-1 exerts considerable anticancer activity against breast cancer cell lines and reduces tumor volume in vivo. STAT3/NF-?B-IN-1 can be used for the study of breast cancer.