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Stearoyl Serotonin
GENERAL CATALOGUE

Stearoyl Serotonin

HY-121465 · 5 mg

MedChemExpress · Cat: HY-121465

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Catalog No: HY-121465
CAS No: 67964-87-8
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress

Description

Stearoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase FAAH and the transient receptor potential vanilloid-type 1 TRPV1 channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with the saturated 18-carbon stearoyl moiety have not been studied. However, replacement of arachidonate with saturated 11- or 12-carbon fatty acids produces compounds that potently inhibit capsaicin-induced TRPV1 channel activation IC50=0.76 ?M without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine IC50 50 ?M.

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