GENERAL CATALOGUE
SZU-B6
HY-168574 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-168574
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medchemexpress.com/szu-b6.htmlCatalog No: HY-168574
CAS No: 3059333-98-8
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
SZU-B6 is a PROTAC degrader for SIRT6 with DC50 of 45 nM and 154 nM in cell SK-HEP-1 and Huh-7. SZU-B6 inhibits the proliferation of cell SK-HEP-1 with an IC50 of 1.51 ?M, inhibits the colony formation of SK-HEP-1 and Huh-7, induces apoptosis and arrests the cell cycle at G2/M phase in SK-HEP-1. SZU-B6 exhibits antitumor efficacy in mouse model. Pink: ligand for target protein HY-16605 ; Black: linker HY-W012935 ; BLue: ligand for E3 ligase HY-W453548
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