GENERAL CATALOGUE
T025
HY-112296 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-112296
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Catalog No: HY-112296
CAS No: 2407433-00-3
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase CLKs , with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines IC50 values: 30-300 nM . T025 has an anti-tumor efficiency, mainly for MYC-driven disease research.
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