GENERAL CATALOGUE
T6167923
HY-19744 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-19744
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Catalog No: HY-19744
CAS No: 2437475-16-4
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor TIR domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-?B driven Staphylococcus enterotoxin AP SEAP activity, and improves anti-inflammatory activity with IC50s of 2.7 ?M, 2.9 ?M, 2.66 ?M and 2.66 ?M for IFN-?, IL-1?, IL-6 and TNF-?, respectively.
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