GENERAL CATALOGUE
TAK-960 dihydrochloride
HY-15160B · 10 mM * 1 mL in Water
MedChemExpress · Cat: HY-15160B
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medchemexpress.com/TAK-960_dihydrochloride.htmlCatalog No: HY-15160B
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in Water
Brand: MedChemExpress
Description
TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 PLK1 , with an IC50 of 0.8 nM. TAK-960 dihydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 dihydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.