TAK1 Rabbit Monoclonal Antibody

Description

EnkiLife offers the TAK1 Rabbit Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat, species and is suitable for WB,ICC/IF,ELISA,IP application. Alternative Names of Immunogen: MAP3K7;TAK1;Mitogen-activated protein kinase kinase kinase 7;Transforming growth factor-beta-activated kinase 1;TGF-beta-activated kinase 1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1000-1:5000,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000,IP 1:50-1:200 Background: Cell localization:Cytoplasm, Membrane.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],