Taltirelin acetate

Description

Taltirelin acetate TA-0910 is an acetate form of Taltirelin TA-0910 . Taltirelin TA-0910 is an orally effective analogue of thyrotropin releasing hormone TRH and a TRH receptor TRH-R superagonist IC50 at 910 nM . Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca2+ concentration Ca2+ release with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ HY-W008719 or Rotenone HY-B1756 . Taltirelin has neuroprotective effects in both cellular and animal models of Parkinsons disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.