GENERAL CATALOGUE
Tambiciclib
HY-X0009 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-X0009
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Catalog No: HY-X0009
CAS No: 2247481-08-7
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Tambiciclib GFH009, JSH-009 is an orally active, highly potent and selective CDK9 inhibitor IC50 = 1 nM , demonstrating >200-fold selectivity over other CDKs, >100-fold selectivity over DYRK1A/B, and excellent selectivity over 468 kinases/mutants. Tambiciclib demonstrates potent in vitro and in vivo antileukemic efficacy in acute myeloid leukemia AML mouse models by inhibiting RNA Pol II phosphorylation, downregulating MCL1 and MYC, and inducing apoptosis. Tambiciclib can be used for AML research.
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