Tamoxifen-13C6

Description

Tamoxifen-13C6 ICI 47699-13C6 is the 13C-labeled Tamoxifen HY-13757A . Tamoxifen ICI 47699 is an orally active, selective estrogen receptor modulator SERM which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg MARV with IC50 of 0.1 ?M and 1.8 ?M, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER transgenic mouse.