GENERAL CATALOGUE
TAS0728
HY-111553 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-111553
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Catalog No: HY-111553
CAS No: 2088323-16-2
Category: JAK STAT Signaling
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
TAS0728 is a potent, selective, orally active, irreversible and covalent-binding HER2 inhibitor, with an IC50 of 13 nM. TAS0728 also shows IC50s of 4.9, 8.5, 31, 65, 33, 25 and 86 nM for BMX?HER4?BLK?EGFR?JAK3?SLK and LOK respectively. Furthermore, TAS0728 exhibits robust and sustained inhibition of the phosphorylation of HER2, HER3, and downstream effectors.
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