TASIN-1

Description

TASIN-1 is a selective inhibitor of truncated APCTR adenomatous polyposis coli gene that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 specifically targets colorectal cancer CRC cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 exerts cytotoxic effects by targeting Emopamil binding protein EBP to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum ER stress, reactive oxygen species ROS generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 can be used to prevent and intervene in APC mutant colorectal cancer.