TC-I 15

Description

TC-I 15 TC-I-15 is a type of allosteric collagen-binding integrin ?2?1 inhibitor, and it also inhibits ?1?1 and ?11?1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast CAF extracellular vesicles EVs by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma SACC to the lungs in mouse models, .