GENERAL CATALOGUE
TCRS-417
HY-153916 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-153916
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medchemexpress.com/tcrs-417.htmlCatalog No: HY-153916
CAS No: 2032123-28-5
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
TCRS-417 T417 is a small-molecular inhibitor for PBX1. TCRS-417 can directly block PBX1-binding to DNA IC50 = 6.58 ?M , and affects PBX1 transcription. TCRS-417 is able to hammer out the stemness traits of Carboplatin HY-17393 -resistant CR cells to revert to a differentiated status through tacking PBX1 signaling cascade. TCRS-417 significantly suppresses self-renewal and proliferation of cancer cells expressing high levels of PBX1. TCRS-417 can decrease the mRNA levels of FOXM1, NEK2, and E2F2 in cancer cell lines. TCRS-417 is selectively toxic against chr1q-amp myeloma and solid tumor cells.
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