GENERAL CATALOGUE
TDI-012804
HY-173349 · 50 mg
MedChemExpress · Cat: HY-173349
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medchemexpress.com/tdi-012804.html
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Catalog No: HY-173349
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous Tnks1HET and completely knocks out Tnks1KO for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids EC50 of 59.1 nM and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids.
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