GENERAL CATALOGUE
TDI-015051
HY-170524 · 50 mg
MedChemExpress · Cat: HY-170524
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medchemexpress.com/tdi-015051.htmlCatalog No: HY-170524
CAS No: 3052313-73-9
Category: Anti-infection
Pack Size: 50 mg
Brand: MedChemExpress
Description
TDI-015051 is an orally active inhibitor for SARS-CoV-2 nonstructural protein 14 NSP14 with an IC50 ?0.15 nM. TDI-015051 inhibits SARS-CoV-2 NSP14 in Huh-7.5 cell EC50=11.4 nM and in ACE2-TMPRSS2 expressing A549 cell EC50=64.7 nM . TDI-015051 also inhibits other coronaviruses like ?-hCoV-NL63, ?-hCoV-229E and ?-hCoV-MERS with IC50s of 1.7, 2.6 and 3.6 nM, respectively. TDI-015051 binds to the SAH-stabilized cap binding pocket, inhibits viral RNA methylation and viral replication, and exhibits anti-infectious activity in mouse models.
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