Tecovirimat-d4

Description

Tecovirimat-d4 ST-246-d4 is a deuterium-labelled Tecovirimat HY-14805 . Tecovirimat is an orally bioavailable and selective compound against orthopoxviruses including vaccinia, monkeypox, camelpox, cowpox, ectromelia mousepox , smallpox and variola viruses . Tecovirimat is evaluated against vaccinia, cowpox virus, ectromelia virus with EC50 values of 0.01 ?M, 0.48 ?M and 0.05 ?M, respectively. Tecovirimat targets the orthopoxvirus protein VP37 which is necessary for membrane envelopment of intracellular mature virus particles to form enveloped virus. Tecovirimat exerts antiviral activity on the target of the cowpox virus V061 gene, which is homologous to vaccinia virus F13L, encoding a major envelope protein p37 required for production of extracellular virus. Tecovirimat could be used in the study for orthopoxvirus-induced diseases.