GENERAL CATALOGUE
Tegaserod
HY-14153 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-14153
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Catalog No: HY-14153
CAS No: 145158-71-0
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Tegaserod is an orally active serotonin receptor 4 HTR4; 5-HT4R agonist and a 5-HT2B receptor antagonist. Tegaserod has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod has anti-tumor activity and has the potential for irritable bowel syndrome IBS research.
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