GENERAL CATALOGUE
Telaglenastat hydrochloride
HY-12248A · 50 mg
MedChemExpress · Cat: HY-12248A
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medchemexpress.com/telaglenastat-hydrochloride.htmlCatalog No: HY-12248A
CAS No: 1874231-60-3
Category: Autophagy
Pack Size: 50 mg
Brand: MedChemExpress
Description
Telaglenastat CB-839 hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 GLS1 inhibitor. Telaglenastat hydrochloride selectively inhibits GLS1 splice variants KGA kidney-type glutaminase and GAC glutaminase C compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat hydrochloride inudces autophagy and has antitumor activity.
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