GENERAL CATALOGUE
Tenofovir exalidex
HY-109014 · 5 mg
MedChemExpress · Cat: HY-109014
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medchemexpress.com/tenofovir-exalidex.htmlCatalog No: HY-109014
CAS No: 911208-73-6
Category: Anti-infection
Pack Size: 5 mg
Brand: MedChemExpress
Description
Tenofovir exalidex CMX157 is a lipid conjugate of the acyclic nucleotide analog Tenofovir with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. Tenofovir exalidex is active against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC50s ranging between 0.2 and 7.2 nM. CMX157 is orally available and has no apparent toxicity. Tenofovir exalidex also shows antiviral activity against HBV.
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