GENERAL CATALOGUE
Tesevatinib tosylate
HY-13314A · 50 mg
MedChemExpress · Cat: HY-13314A
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medchemexpress.com/tesevatinib-tosylate.htmlCatalog No: HY-13314A
CAS No: 1000599-06-3
Category: JAK STAT Signaling
Pack Size: 50 mg
Brand: MedChemExpress
Description
Tesevatinib XL-647 tosylate is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor EGFR . Tesevatinib tosylate significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib tosylate also inhibits HER2 IC50=16.1 nM , VEGFR2 IC50=1.5 nM , and Src IC50=10.3 nM . Tesevatinib tosylate can inhibit tumor proliferation and exhibits antitumor activity.
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