GENERAL CATALOGUE
TH023
HY-168207 · 50 mg
MedChemExpress · Cat: HY-168207
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Catalog No: HY-168207
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
TH023 is an inhibitor for the TLR4 signaling pathway, that targets especially the formation of TLR4 homodimer. TH023 inhibits secreted embryonic alkaline phosphatase in cell HEK-Blue hTLR4 with an IC50 of 0.354 ?M, and inhibits the NO expression in RAW264.7 with an IC50 of 1.61?M. TH023 also inhibits the activation of NF-?B, reduces the nuclear translocation of NF-?B p65. TH023 exhibits anti-inflammatory efficacy in LPS HY-D1056 -induced mouse acute sepsis model, and ameliorates the mouse lung injury.
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