GENERAL CATALOGUE
TH5427 hydrochloride
HY-125209A · 50 mg
MedChemExpress · Cat: HY-125209A
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medchemexpress.com/th5427-hydrochloride.htmlCatalog No: HY-125209A
CAS No: 2253744-57-7
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor IC50=29 nM . TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.
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