GENERAL CATALOGUE
TH6342
HY-161296 · 1 mg
MedChemExpress · Cat: HY-161296
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Catalog No: HY-161296
Category: Anti-infection
Pack Size: 1 mg
Brand: MedChemExpress
Description
TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe.
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