Thalidomide-4-O-CH2-COO(t-Bu)

Description

Thalidomide-4-O-CH2-COO t-Bu is t-Bu modified Thalidomide HY-14658 , which is the final step intermediate in the synthesis of Thalidomide-4-OH HY-123096 . Thalidomide-4-O-CH2-COO t-Bu acts as a Cereblon ligand to recruit CRBN proteins. The t-Bu protecting group at the end of Thalidomide-4-O-CH2-COO t-Bu can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-O-CH2-COO t-Bu is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules.