Thalidomide-5-O-CH2-COO(t-Bu)

Description

Thalidomide-5-O-CH2-COO t-Bu is a t-Bu modified Thalidomide HY-14658 , which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-O-CH2-COO t-Bu can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-O-CH2-COO t-Bu is a key intermediate in the synthesis of CRBN-based PROTAC molecules.