GENERAL CATALOGUE
THIQ
HY-10624 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-10624
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Catalog No: HY-10624
CAS No: 312637-48-2
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
THIQ is the first selective agonist of the melanocortin-4 receptor MC4R , with high affinity and potency for hMC4R IC50=1.2 nM, EC50=2.1 nM and rMC4R IC50=0.6 nM, EC50=2.9 nM . THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants.
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