GENERAL CATALOGUE
TIC10g
HY-162649 · 50 mg
MedChemExpress · Cat: HY-162649
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Catalog No: HY-162649
CAS No: 754998-88-4
Category: Immunology Inflammation
Pack Size: 50 mg
Brand: MedChemExpress
Description
TIC10g is a dual inhibitor for toll-like receptor 7 and 9 TLR7 and TLR9 , which inhibits TLR7 and TLR9 mediated TNF-? release in mouse macrophages IC50 is 14.5 ?M and 6.5 ?M and human B lymphocytes IC50 is 7.69 ?M and 11.5 ?M . TIC10g inhibits the activation of NF-?B and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis .