GENERAL CATALOGUE
Tinlorafenib
HY-147405 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-147405
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medchemexpress.com/tinlorafenib.html
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Catalog No: HY-147405
CAS No: 2573781-75-4
Category: MAPK ERK Pathway
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Tinlorafenib PF-07284890 is the orally active inhibitor for BRAF and CRAF with IC50s of 5.8 nM and 4.1 nM. Tinlorafenib Compound 10 inhibits V600E mutated BRAF and V600K mutanted BRAF with IC50s of 4.25 nM and 2.7 nM. Tinlorafenib can cross the blood brain barrier. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies.
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